Medicinal and pharmaceutical preparation.



, 5proportion of calcium hydro'xid and-.creo

- i inseam.

UNrTE sr TEs PATENT OFFICE.

. ntense y Lf'MALr-BIE, on nAs'r ORANGE, NEW JERSEY.

MEDICINAL Ann PHARMACEUTICAL PREPARATION.

No- Drawing;

To (all whom it may concern:

Be it known that I, BIRDSEY L. MALTBIE, a natural born citizen of the United States of America, residing at East Orange, in the county-of Essex and State of New Jersey, have invented certain new and usGfuLIIH- prorements in Medicinal and Pharmaceutical Preparations,.of whichthe following is a specification.

This invention relates to a new chemical and medicinal preparation and'has for its object the combining chemically of beechwood creosote and calcium hydrate. The elements of the creosote and calcium hydroxid are broken up and a mixture of new chemical combinations formed, this mixture of new chemical combinations usually being in the form of a granular powder and having a reddish brown color.

. Physical evidence of the formation, in the product, of new chemical combinations lies in the fact that colorless beechwoodcreosoteand calcium hydroxid, which is also colorless, when mixed in chemlcal proportions- 'form a reddish brown hard substance, vwhich is reducible to a granular powder.

That new chemical combinations are formed is further illustrated by the following formula: p v 3 oqocsnacmocng oH+oa .0o6H.0oHa oH+ which represents the chemical formula of the calcium compounds of mono-methyl ethers. of the substituted polyhydric phenols present, and is the product described when equal portions by weight of calcium hydroxid and creosote are combined in the presence of water. I do not, however,confine myself-to the use of equal proportions by Weight of calcium hydroxid and creo s0te;' when, for instance, I use an increased proportion of calcium hydroxid with creosote in thepresence of water, the combination is represented by the following formula: I

sote as above stated. I sometimes change the sote. in the presence of water, the same chemical combinations taking place without the addition of the water.

combinatioiis which take place, forming the Specification of Letters Patent. PatentedDec;24,1.1912. 7 application filed any 7, 1912. Serial No. 695,705.

combination of calcium-'hydroxidand creo i These formulas illustrate the chemical calcium compounds ofcreosol and guaiacol,

and called respectively calcium creosote and calcium guaiacate, calcium carbolate also being formed; the calcium carbolate is a well-known salt, but the calcium creosate and calcium guaiacate are new.

-A specific process for making the prepa ration is as follows: I take equal. partsvby" weight" of calcium oxid -and beechwood creosote. To this I add water, one of the functions of which ist-o change the calcium oxid into calcium hydroxid.; The compound -is then-quickly dried in the open air and granulated. .The addition ofwater is not essential when I use calcium hydroxid. In

the above process I do not confine myself,

"is I as abovesta-ted, to the use of equal quantities by' weight of calcium oxid (or calcium hydroxid) and-beechwood creosote.

Creosote is recognized by medical authoris ties as one of the most valuable remedies for tuberculosis, bronchitis and kindred dis eases, but-it'has had comparatively limited use because of the inability to administer it in sufiicient quantity to produce results,

nausea and'vomiting resulting from large doses. By chemically combining creosote with calcium hydroxid,'I have-very largely overcome this objection to creosote and have provided. a new chemicalocompound which may be administered in doses of suflicient size to produce the desired results.

The essential features of my invention COIISISt 1n the chemical combination. of creosote and calcium hydroxid, theproportions of the ingredients of the compound'being varied, as the occasion requires. 7

Guaiacolfand creosol arephenol monomethyl-ethers, using the word .phenol to include both benzophenol and "toluophenol. I

The term calciumphenol mono methylother is therefore used in claim 1 to denote 105, 'Having thus described my invention, what either calcium guaiacate or creosote.

Iclaim is, 1. A medicinal --p calcium-phen0l-mon0- th 1 J 4 p medicinal preparation "containing a parationconsisting of): 3

calcium :salt of a", substituted' polyhydric phenol which contains' the-radical O; CH

3. Amedicinal cium creosate.

i. A medicinal preparation containing calcium creosate and calcium guaiacate.

5. The process of making medicinal preparations, which consists in mixing a basic preparation containing calcalcium compound with beechwood creosote,

3.3116. forming a product containing the call cium compounds of creosol and guaiacol.

6. The process of making medicinal preparations, whlch consists in mixing calcium oxid with beechwood creosote and adding suflicient water to form calcium hydroxid, thereby forming a product containing the calcium compounds of creosol, guaiacol and 15 phenol.

In testimony whereof said BIRDSEY L. MALTBIE has hereunto aflixed his signature in the presence of two witnesses.

B'IRDSEY L; MALTBIE.

Witnesses I W. C. WARiwER, J. H. For. I 

